Why photoreceptors die (and why they don't)

Article Abstract:

Experiments reveal that the rod apoptosis could be triggered by strong and constant activation of transduction, and that death could be prevented if transduction is inhibited even though the eye is illuminated. To prevent death in constant light, rods have evolved protective mechanisms including modulation of channels and ion transport to keep the Ca(super 2+) from going too low.

California, Analysis, Physiological aspects, Ultraviolet radiation, Rods (Photoreceptors)

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Notch and NF[kappa]B signaling pathways: do they collaborate in normal vertebrate brain development and function?

Article Abstract:

Notch and NF[kappa]B are signaling pathways with various common features that are used for regulating cellular events like proliferation and apoptosis. They are also found to highly collaborate in regulating the normal development and function of the brain in vertebrates.

Brain research, Phosphotransferases

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Breast cancer and Metabolic Syndrome linked through the plasminogen activator inhibitor-1 cycle

Article Abstract:

The effects of upregulation of the plasminogen activator inhibitor-1 (PAI-1) as a consequence of the Metabolic Syndrome (MetS) are reported. The analysis shows that PAI-1 regulated through MetS leads to a more aggressive predisposition of breast cancer in a patient.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Blood Clot Dissolvers, Risk factors, Genetic aspects, Breast cancer, Fibrinolytic agents, Thrombolytic drugs, Metabolic syndrome X

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